The diagnosctic incredibly early main symptomatic infections is of hiv big curiosity in enabling a fast reaction by remedy with a sizeable impact on the enhancement of infection.

Also, an asymptomatic affected person can come stop by on the "risk taking", generally sexual, but in addition a shared syringe, an injury to care, and so on. .... The dilemma of "ART immediately after exposure." poser.Il will no extended reserved for qualified contamination and calls for referral to an emergency section or hospital doctor referral. Its achievement will depend upon how early the get started (as soon as possible, ideally in twelve hrs, at worst inside 48 hrs) and the stringent observance
In apply, risk assessment might be hard and - no less than - a phone contact with the referent a clever perspective
No matter what the judgement, administration need to integrate the therapeutic aspects, social and psychological.

SEMIOLOGY
Clinical signs normally start off throughout the 15th day soon after infection. but will not be really unique.
$ $ Flu-like or suggestive of MNI
---- Fever, headache, asthenia
---- Potentially: rash (rash), ulceration with the oral mucosa or genital
---- Many a number of adenopathies appearing in the second week of development.
Diarrhea and oral candidiasis ---- a lot less regular but evocative
---- The neurological sorts early, unusual, often critical
The disease progresses through many weeks

BIOLOGY

* The p24 antigenicity may be the gold common of diagnosis of main infection.
It is current in 90% of instances J14 and precedes the overall look of antibodies from 8 to 30 days
the agP24 disappears after 10 days if the antibodies appear
Its positivity leads to hospitalization inside of a specialized middle.
* Attach an antibody anti-HIV by ELISA. Its positivity is doable J22-26 following infection. It must be confirmed by a Western blot. It really is practiced for reference reasons only. His negativity with this early phase just isn't intelligence.
* Note: the hunt for HIV RNA is just not indicated while in the diagnostic stage. It will be carried out inside pre-therapeutic and monitoring of the affected person

Favourable BIOLOGY
Hospitalization within a specialized rapidly.

BIOLOGY Bad
The negativity in the two exams (AC agP24 and anti HIV) is not going to eliminate 100% contamination
Vigilance, prevention recommendations and psychological assistance need to be preserved.
Only for anti-HIV by ELISA three months after the coverage will never say a diagnosis of contamination.
Concern: The hunt for HIV RNA permits it to shorten the waiting period of time? Only the opportunity of false positives appears to be to have been described.

If chance evaluation crucial decision a "antiviral treatment method after exposure" really should be taken and so needs the intervention of a hospital physician referral.